GUI scalability
For the most part of the history of desktop application development, specifying sizes of GUI elements in pixels was the common practice. While most operating systems had dots per inch (DPI) settings and APIs for taking it into account for a long time, the majority of existing displays had approximately the same DPI, so applications without high DPI support were common.
The situation changed when high-DPI displays became more common in the market—most notably in mobile phones and tablets, but also in laptops and desktops. Now, even if you only target desktop platforms, you should think about supporting different DPI settings. When you target mobile devices, this becomes mandatory.
If you are using Qt Widgets or Qt Quick, you often don't need to specify pixel sizes at all. Standard widgets and controls will use fonts, margins, and offsets defined by the style. If layouts are used, Qt will determine positions and sizes of all GUI items automatically. Avoid specifying constant sizes for GUI elements when possible. You may use sizes related to sizes of other GUI elements, the window, or the screen. Qt also provides an API for querying screen DPI, GUI style metrics, and font metrics, which should help to determine the optimal size for the current device.
On macOS and iOS, Qt Widgets and Qt Quick applications are scaled automatically using a virtual coordinate system. Pixel values in the application remain the same, but the GUI will scale according to the DPI of the current display. For example, if the pixel ratio is set to 2 (a common value for retina displays), creating a widget with 100 "pixels" width will produce a widget with 200 physical pixels. That means that the application doesn't have to be highly aware of DPI variations. However, this scaling does not apply to OpenGL, which always uses physical pixels.