Cell is the basic unit of life.Most epithelial and non-epithelial cells have abilities to move slowly with micro-motion force and to locomote through intercellular spaces and connective fibers is adhering with the adjacent cells and fibers.These cellular behaviors and activities are fully associated with aging，heal of wounds，embryogenesis，immune reaction，infection and cancer metastasis.Cell migration is directional movement by extracellular shape transition after receiving migration signals or catching certain substances concentration gradient.The study of cell migration is therefore helpful for understanding the process of cancer metastasis.