参考文献

［1］O’Donnell MJ，Xavier D，Liu L，et al.Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries（the INTERSTROKE study）：a case-control study.Lancet，2010，376（9735）：112-123.

［2］Yong H，Foody J，Linong J，et al.A systematic literature review of risk factors for stroke in China.Cardiol Rev，2013，21（2）：77-93.

［3］Thomopoulos C，Parati G，Zanchetti A.Effects of blood pressure lowering on outcome incidence in hypertension.1.Overview，meta-analyses，and meta-regression analyses of randomized trials.J Hypertens，2014，32（12）：2285-2295.

［4］Wu Y，Huxley R，Li L，et al.Prevalence，awareness，treatment，and control of hypertension in China：data from the China National Nutrition and Health Survey 2002.Circulation，2008，118（25）：2679-2686.

［5］Lewington S，Lacey B，Clarke R.Uncontrolled Hypertension and Risk of Cardiovascular Mortality in China-Reply.JAMA Intern Med，2016，176（8）：1234.

［6］Lonn EM，Bosch J，Lopez-Jaramillo P，et al.Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease.N Engl J Med，2016，374（21）：2009-2020.

［7］Lawes CM，Bennett DA，Feigin VL，et al.Blood pressure and stroke：an overview of published reviews.Stroke，2004，35（3）：776-785.

［8］Turnbull F.Effects of different blood-pressure-lowering regimens on major cardiovascular events：results of prospectively-designed overviews of randomised trials.Lancet，2003，362（9395）：1527-1535.

［9］Sundstrom J，Arima H，Woodward M，et al.Blood pressurelowering treatment based on cardiovascular risk：a meta-analysis of individual patient data.Lancet，2014，384（9943）：591-598.

［10］Selhub J，Jacques PF，Rosenberg IH，et al.Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey（1991-1994）：population reference ranges and contribution of vitamin status to high serum concentrations.Ann Intern Med，1999，131（5）：331-339.

［11］Pfeiffer CM，Johnson CL，Jain RB，et al.Trends inblood folate and vitamin B-12 concentrations in the United States，1988 2004.Am J Clin Nutr，2007，86（3）：718-727.

［12］KokuboY.Prevention of Hypertension and Cardiovascular Diseases：A Comparison of Lifestyle Factors in Westerners and East Asians.Hypertension，2014，63（4）：655-660.

［13］Thomopoulos C，Parati G，Zanchetti A.Effects of bloodpressure lowering on outcome incidence in hypertension：4.Effects of various classes of antihypertensive drugs--overview and meta-analyses.JHypertens，2015，33（2）：195-211.

［14］Huo Y，Li J，Qin X，et al.Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China：the CSPPT randomized clinical trial.JAMA，2015，313（13）：1325-1335.

［15］Lithell H，Hansson L，Skoog I，et al.The Study on Cognition and Prognosis in the Elderly（SCOPE）：principal results of a randomized double-blind intervention trial.J Hypertens，2003，21（5）：875-886.

［16］Dahlof B，Devereux R B，Kjeldsen S E，et al.Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint reduction in hypertension study（LIFE）：a randomised trial against atenolol.Lancet，2002，359（9311）：995-1003.

［17］Kuyper LM，Khan NA.Atenolol vs nonatenolol beta-blockers for the treatment of hypertension：a meta-analysis.Can J Cardiol，2014，30（5 Suppl）：S47-S53.

［18］Huang Y，Cai X，Li Y，et al.Prehypertension and the risk of stroke：A meta-analysis.Neurology，2014，82（13）：1153-61.

［19］Wright JJ，Williamson JD，Whelton PK，et al.A Randomized Trial of Intensive versus Standard Blood-Pressure Control.N Engl J Med，2015，373（22）：2103-2116.

［20］Fischer U，Cooney MT，Bull LM，et al.Acute post-stroke blood pressure relative to premorbid levels in intracerebral haemorrhage versus major ischaemic stroke：a population-based study.Lancet Neurol，2014，13（4）：374-384.

［21］Zhang Y，Reilly KH，Tong W，et al.Blood pressure and clinical outcome among patientswith acute stroke in Inner Mongolia，China.J Hypertens，2008，26（7）：1446-1452.

［22］Anderson CS，Huang Y，Arima H，et al.Effects of early intensive blood pressure-lowering treatment on the growth of hematoma and perihematomal edema in acute intracerebral hemorrhage：the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial（INTERACT）.Stroke，2010，41（2）：307-312.

［23］Anderson CS，Heeley E，Huang Y，et al.Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage.N Engl J Med，2013，368（25）：2355-2365.

［24］Sakamoto Y，Koga M，Yamagami H，et al.Systolic blood pressure after intravenous antihypertensive treatment and clinical outcomes in hyperacute intracerebral hemorrhage：the stroke acute management with urgent risk-factor assessment and improvement-intracerebral hemorrhage study.Stroke，2013，44（7）：1846-1851.

［25］McCourt R，Gould B，Gioia L，et al.Cerebral perfusion and blood pressure do not affect perihematoma edema growth in acute intracerebral hemorrhage.Stroke，2014，45（5）：1292-1298.

［26］Qureshi AI，Palesch YY，Barsan WG，et al.Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage.N Engl J Med，2016，375（11）：1033-1043.

［27］Manning L，Hirakawa Y，Arima H，et al.Blood pressure variability and outcome after acute intracerebral haemorrhage：a post-hoc analysis of INTERACT2，a randomised controlled trial.Lancet Neurol，2014，13（4）：364-373.

［28］Mazya M，Egido JA，Ford GA，et al.Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase：safe Implementation of Treatments in Stroke（SITS）symptomatic intracerebral hemorrhage risk score.Stroke，2012，43（6）：1524-1531.

［29］Menon BK，Saver JL，Prabhakaran S，et al.Risk score for intracranial hemorrhage in patients with acute ischemic stroke treated with intravenous tissue-type plasminogen activator.Stroke，2012，43（9）：2293-2299.

［30］Potter JF，Robinson TG，Ford GA，et al.Controlling hypertension and hypotension immediately post-stroke（CHHIPS）：a randomised，placebo-controlled，double-blind pilot trial.Lancet Neurol，2009，8（1）：48-56.

［31］He J，Zhang Y，Xu T，et al.Effects of Immediate Blood Pressure Reduction on Death and Major Disability in Patients with Acute Ischemic Stroke：The CATIS Randomized Clinical Trial.JAMA，2013，311（5）：479-489.

［32］Bath PM，Woodhouse L，Scutt P，et al.Efficacy of nitric oxide，with or without continuingantihypertensive treatment，for management of high blood pressure in acute stroke（ENOS）：a partial-factorial randomised controlled trial.Lancet，2015，385（9968）：617-628.

［33］Robinson TG，Potter JF，Ford GA，et al.Effects of antihypertensive treatment after acute stroke in the Continue or Stop Post-Stroke Antihypertensives Collaborative Study（COSSACS）：a prospective，randomised，open，blinded-endpoint trial.Lancet Neurol，2010，9（8）：767-775.

［34］Sandset EC，Bath PM，Boysen G，et al.The angiotensin-receptor blocker candesartan for treatment of acute stroke（SCAST）：a randomised，placebo-controlled，double-blind trial.Lancet，2011，377（9767）：741-750.

［35］Hornslien AG，Sandset EC，Igland J，et al.Effects of candesartan in acute stroke on vascular events during long-term follow-up：results from the Scandinavian Candesartan Acute Stroke Trial（SCAST）.Int J Stroke，2015，10（6）：830-835.

［36］Lee M，Ovbiagele B，Hong KS，et al.Effect of Blood Pressure Lowering in Early Ischemic Stroke：Meta-Analysis.Stroke，2015，46（7）：1883-1889.

［37］Wang H，Tang Y，Rong X，et al.Effects of early blood pressure lowering on early and long-term outcomes after acute stroke：an updated meta-analysis.PLoS One，2014，9（5）：e97917.

［38］Rashid P，Leonardi-Bee J，Bath P.Blood pressure reduction and secondary prevention of stroke and other vascular events：a systematic review.Stroke，2003，34（11）：2741-2748.

［39］Post-stroke antihypertensive treatment study.A preliminary result.Chin Med J（Engl），1995，108（9）：710-717.

［40］Arima H，Chalmers J，Woodward M，et al.Lower target blood pressures are safe and effective for the prevention of recurrent stroke：the PROGRESS trial.J Hypertens，2006，24（6）：1201-1208.

［41］王文，邓卿，王宪衍，等.6年降压治疗对脑血管病患者脑卒中再发事件的预防效果.中华高血压杂志，2007，15（4）：281-284.

［42］Ovbiagele B，Diener HC，Yusuf S，et al.Level of systolic blood pressure within the normal range and risk of recurrent stroke.JAMA，2011，306（19）：2137-2144.

［43］Thomopoulos C，Parati G，Zanchetti A.Effects of blood pressure lowering on outcome incidence in hypertension：2.Effects at different baseline and achieved blood pressure levels--overview and meta-analyses of randomized trials.JHypertens，2014，32（12）：2296-2304.

［44］Thomopoulos C，Parati G，Zanchetti A.Effects of blood pressure lowering on outcomeincidence in hypertension：7.Effects of more vs.less intensive blood pressure lowering and different achieved blood pressure levels-updated overview and metaanalyses of randomized trials.J Hypertens，2016，34（4）：613-622.

［45］Ettehad D，Emdin CA，Kiran A，et al.Blood pressure lowering for prevention of cardiovascular disease and death：a systematic review and meta-analysis.Lancet，2016，387（10022）：957-967.

［46］Xie X，Atkins E，Lv J，et al.Effects of intensive blood pressure lowering on cardiovascular and renal outcomes：updated systematic review and meta-analysis.Lancet，2016，387（10017）：435-443.

［47］Yano Y，Briasoulis A，Bakris GL，et al.Effects of antihypertensive treatment in Asian populations：a meta-analysis of prospective randomized controlled studies（CARdiovascular protectioN group in Asia：CARNA）.J Am Soc Hypertens，2014，8（2）：103-116.

［48］Taylor J.2013 ESH/ESC guidelines for the management of arterial hypertension.Eur Heart J，2013，34（28）：2108-2109.

［49］中国高血压防治指南修订委员会.中国高血压防治指南2010.中华心血管病杂志，2011，39（7）：579-616.

［50］James PA，Oparil S，Carter BL，et al.2014 evidence-based guideline for the management of high blood pressure in adults：report from the panel members appointed to the Eighth Joint National Committee（JNC 8）.JAMA，2014，311（5）：507-520.

［51］Thom S，Poulter N，Field J，et al.Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD：the UMPIRE randomized clinical trial.JAMA，2013，310（9）：918-929.

［52］Yamauchi H，Higashi T，Kagawa S，et al.Impaired perfusion modifies the relationship between blood pressure and stroke risk in major cerebral artery disease.J Neurol Neurosurg Psychiatry，2013，84（11）：1226-1232.

［53］Powers WJ，Clarke WR，Grubb RJ，et al.Lower stroke risk with lower blood pressure in hemodynamic cerebral ischemia.Neurology，2014，82（12）：1027-1032.

［54］Mancia G，Grassi G.Aggressive blood pressurelowering is dangerous：the J-curve：pro side of the arguement.Hypertension，2014，63（1）：29-36.

［55］Brunstrom M，Carlberg B.Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus：systematic review and meta-analyses.BMJ，2016，352：i717.

［56］Emdin CA，Rahimi K，Neal B，et al.Blood pressure lowering in type 2 diabetes：asystematic review and meta-analysis.JAMA，2015，313（6）：603-615.

［57］Bangalore S，Fakheri R，Toklu B，et al.Diabetes mellitus as a compelling indication for use of renin angiotensin system blockers：systematic review and meta-analysis of randomized trials.BMJ，2016，352：i438.

［58］Liu L，Wang JG，Gong L，et al.Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension.Systolic Hypertension in China（Syst-China）Collaborative Group.J Hypertens，1998，16（12 Pt 1）：1823-1829.

［59］Beckett NS，Peters R，Fletcher AE，et al.Treatment of hypertension in patients 80 years of age or older.N Engl J Med，2008，358（18）：1887-1898.

［60］Briasoulis A，Agarwal V，Tousoulis D，et al.Effects of antihypertensive treatment in patients over 65 years of age：a meta-analysis of randomised controlled studies.Heart，2014，100（4）：317-323.

［61］Bangalore S，Gong Y，Cooper-DeHoff RM，et al.2014 Eighth Joint National Committee panel recommendation for blood pressure targets revisited：results from the INVEST study.J Am Coll Cardiol，2014，64（8）：784-793.

［62］Turnbull F，Neal B，Ninomiya T，et al.Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults：meta-analysis of randomised trials.BMJ，2008，336（7653）：1121-1123.

［63］Williamson JD，Supiano MA，Applegate WB，et al.Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years：A Randomized Clinical Trial.JAMA，2016，315（24）：2673-2682.

［64］高血压联盟中国，国家心血管病中心，中华医学会心血管病学分会，等.中国高血压患者教育指南.中国医学前沿杂志（电子版），2014，（3）：78-106.

［65］Lackland DT，Roccella EJ，Deutsch AF，et al.Factorsinfluencing the decline in stroke mortality：a statement from the american heart association/american stroke association.Stroke，2014，45（1）：315-353.

［66］McManus RJ，Mant J，Haque MS，et al.Effect of self-monitoring and medication self-titration on systolic blood pressure in hypertensive patients at high risk of cardiovascular disease：the TASMIN-SR randomized clinical trial.JAMA，2014，312（8）：799-808.

［67］McManus RJ，Mant J，Bray EP，et al.Telemonitoring and selfmanagement in the control of hypertension（TASMINH2）：a randomised controlled trial.Lancet，2010，376（9736）：163-172.