1.Shin-ya K.Telomerase inhibitor,telomestatin,a specificmechanism to interactwith telomere structure.Nippon Rinsho,2004,62(7):1277-1282.

2.Yu R,Melmed S.Pituitary tumor transforming gene:an update.Front Horm Res,2004,32:175-185.

3.Ferris RL,Simental AA Jr.Molecular biology of primary hyperparathyroidism.Otolaryngol Clin North Am,2004,37(4):819-831.

4.Arock M.Mastocytosis:advances in molecular diagnosis and therapeutics.Ann Pharm Fr,2004,62(4):233-243.

5.Putzer BM,Drosten M.The RET proto-oncogene:a potential target formolecular cancer therapy.Trends Mol Med,2004,10(7):351-357.

6.Chanan-Khan A,Czuczman MS.Bcl-2 antisense therapy in B-cell malignant proliferative disorders.Curr Treat Options Oncol,2004,5(4):261-267.

7.Jacobson-Kram D,Sistare FD,Jacobs AC.Use of transgenic mice in carcinogenicity hazard assessment.Toxicol Pathol,2004,32(1):49-52.

8.Boisvert WA.Modulation of atherogenesis by chemokines.Trends Cardiovasc Med,2004,14(4):161-165.

9.Verschuren EW,Jones N,Evan GI.The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin.JGen Virol,2004,85(6):1347-1361.

10.Mocellin S,Mandruzzato S,Bronte V,et al.Part I:Vaccines for solid tumours.Lancet Oncol,2004,5(11):681-689.

11.Yamanaka R,Yajima N,Abe T,et al.Dendritic cell-based glioma immunotherapy.Int JOncol,2003,23(1):5-15.

12.Wysocki PJ,Karczewska A,Mackiewicz A.Gene modified tumor vaccines in therapy ofmalignantmelanoma.Otolaryngol Pol,2002,56(2):147-153.

13.Ogasawara S,Tamura G,Maesawa G,etal.Common deleted region on the arm of chromosome 5 in esophageal carcinoma.Gastroerology,1996,110(1):52-57.

14.Huang Y,Boynton R F,Blunt PL,et al.Loss of heterozygosity involvesmultiple tumor suppressor genes in human esophageal cancer.Cancer Res,1992,52(47):6525-6530.

15.Greenwald BD,Harpaz N,Yin J,et al.Loss of heterozygosity affecting the p53,Rb and APC/MCC tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.Cancer Res,1992,52(47):741-745.

16.Ashton Rickardt PG,Wyllie AH,Bird CC,et al.MCC,candidate familial polyposis gene in 5q21,show frequent allele loss in colorectal and lung cancer.Oncogene,1991,6(10):1881-1886.

17.杨沛,王世阆,王靖华,等.卵巢浆液性囊腺癌中MTS1/P16基因突变及其蛋白表达的研究.现代妇科进展,2000,9(3):15-17.

18.Elisabeth B,Adrieu N.Apoptosis related factors p53 Bcl22 and baxin neuroeudocrine lung tumors.American Journal of Pathology,1996,149(24):1941-1952.

19.Eric G,Steven J,Anderson,etal.Bcl2 counters Apoptosis by Bax Het2 erodimerization dependent and independent mechanisms in the Tcell lineage.The Jonrnal of Biological Chemistry,1997,14(12):29347-29355.

20.Hockenberry DM,Zutter M,Hickry W,et al.Bcl22 protein is topographically restricted in tissue characterized by apoptotic cell death.Proc Natl Acad,1991,88(9):6961-6965.

21.Karyu A,Susan E,Daniel.Upregulation of anti2apoptotic protein Bcl2may be an early event in neurodegeneration.Biochemical and Biophysical Research Communications,1997,240(1):84-87.

22.Chung DC.Cyclin D1 in human neuroendocrine:tumorigenesis.Ann N Y Acad Sci,2004,1014(2):209-217.

23.Thomas S,Linda S,Stanley K.Bax enhances paclitax2 induced apoptosis through a p53 independent pathway.Procnatl Acad Sci,1996,193(54):14094-14099.

24.Sedlak TW,Octvaiz N,Yang E,et al.multiple Bcl-2 family members demonstrate selective dimerization with Bax.Proc Natl Acad Sci,1995,93(5):783-788.

25.Yin CM,Korsmeyers J.Bax suppresses tumorgensis and stimulates apoptosis in vivo.Nature,1997,385(5):637-640.

26.杨毅,沈坚,郎景和.细胞凋亡与妇科肿瘤.中华妇产科杂志,1997,32(2):121-123.

27.李佩玲,王雪卿,王姣玲,等.抗细胞凋亡基因BcL-2和Bax卵巢肿瘤的关系.哈尔滨医科大学学报,2000,34(3):174-176.

28.张利能,查锡良.人肝细胞癌中抑癌基因PTEN/MMAC1/TEMP1的突变分析.实验生物学报,2000,33(3):201-203.

29.Mizutani T,Onda M,Tokunaga A,et al.Relationship of CerbB-2 protein expression and amplification to invasion and metastasis in human gastric cancer.Cancer,1993,72(7):2083-2086.

30.石开虎,周久华,颜林洲,等.癌基因C-erbB-2和ras P21与肺癌的相关分析.安徽医学,2000,21(5):210-212.

31.Sheng ZM,Barrois M,klijanienko J,etal.Analysis of the Cha2ras21 gene for deletion/mutation/amplification and expression in lymph node metastases of human head and neck carcinoma.Br JCancer,1990,62(3):98-104.

32.Fontana JA,Miranda D,Mezu AB.Retinoic acid inhibition of human breast carcinoma proliferation is accompanied by inhibition of the synthesis of a Mr 3900 protein.Cancer Res,1990,50(7):1977-1983.

33.Feliciello A,Segfrid M,Lee D,et al.The v2ki2Ras oncogene alters cAMP nuclear signaling by regulating the location and the expression of cAMP dependent protein kinaseⅡbeta.JBiol Chem,1996,271(41):25350-25359.

34.Kagaya S,Martin R.Apoptosis induced by myc family genes.Nippon Rinsho,1996,54(7):1865-1875.

35.Weaver AM,Jahare S,Benjamy F,et al.Epidermal growth factor and platelet-derived growth factor2BB induced a stable increase in the activity of low density lipoprotein receptor2related protein in vascular smooth muscle cells by altering receptor distribution and recycling.JBiol Chem,1996,271(40):24894-24900.

36.Meltzer ST,Yin J,Huang Y,et al.Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.Proc Nat Acad Sci USA,1991,88(11):4976-4980.

37.Wang TH,Zhao GF,Wang T,et al.p53 apoptosis and hyman cancers.JFormos Med Assoc,1996,24(127):320-324.

38.Matsui SI.DNA damage and p53 induction do not cause 2D16942induced cell cycle arrest in human colon carcinoma cells.Cancer Res,1996,56(20):4715-4723.

39.Ribin M.92cis retinoic acid inhibits growth of breast cancer cells and down regulates estrogen receptor RNA and protein.Molecular and Cell Differentiation,1994,1(5):412-419.

40.Lippman SM,Benner SE,Hong WK.Retinoids in chemoprevention of head and neck carcinogenesis.Prev Med,1993,22(5):693-698.

41.Malik K,Brown KW.Epigenetic gene deregulation in cancer.Brit J Cancer,2000,83(11):1583-1588.

42.Esteller M,Corn PG,Baylis SB,et al.A gene hypermethylation profile of human cancer.Cancer Res,2001,61(35):3225-3229.

43.Eads CA,Lord RV,Wickramasinghe K,et al.Epigenetic patterns in the progression of esophageal adenocarcinoma.Cancer Res,2001,61(31):3410-3418.

44.徐建业,周琦,卢萍,等.细胞分化剂对肿瘤细胞凋亡诱导与耐药性的逆转.中华内科杂志,2000,39(1):37-39.

45.徐建业,周琦,卢萍,等.加温诱导肿瘤细胞凋亡与逆转多药耐药的实验研究.中华理疗杂志,2000,23(2):33-36.

46.Corn PG,Kuerbitz SJ,van Noesel MM,et al.Transcriptionalsilencing of the p53 gene in acute lymphoblaslic leukemia and Burkitt's lymphoma.Cancer Res,1999,59(29):3352-3356.

47.Rosas SLB,Koch W,Carvalho MGC,et al.Promoter hypermethylation patterns of p16,O6-methylguanine-DNA-methyltransferase,and death-associated protein kinase in tumors and saliva of head and neck cancer patients.Cancer Res,2001,61(4):939-942.

48.Graff JR,Greenberg VE,Herman JG,etal.Distinctpatterns of E-cadherin CpG islandmethylation in papillary,follicular,Hurthle's cell,and poorly differentiated human thyroid carcinoma.Cancer Res,1998,58(27):2063-2066.

49.Low W,Krill D,Dhir R,etal.Methylation of the CD44metastasis suppressor gene in human prostate cancer.Cancer Res.1999,59(10):2329-2331.

50.孙婧璟,周信达,刘银坤,等.细胞分化诱导剂防治裸鼠肝癌转移复发的疗效.中华肝胆外科杂志,1999,5(1):14-16.

51.Liau MC,Huang LJ,Lee JH,etal.Developmentof differentiation helper inducers for cancer therapy.Chinese Pharm J.1998,50(3):289-303.

52.佐野金兼太郎.消灭癌症.台北:世茂出版社,1997.

53.Sales KM,Winslet MC and Seifalian AM.Stem cells and cancer:An overview.STEM CELL REV,2007,3(4):249-255.

54.Boman BM.Cancer stem Cells:A Step Toward the Cure.JClin Oncol,2008,26:2795-2799.

55.Dalerba P,Cho RW,Clarke MF.Cancer stem Cells:Models and Concepts.Annu Rev Med,2007,58:267-284.

56.Balic M,Lin H,Young L,et al.Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype.Clin Can Res.2006,12:5615-5621.

57.Christiansenl JJ and Rajasekaran AK.Reassessing Epithelial to Mesenchymal Transition as a prerequisite for carcinoma Invasion and Metastasis.Cancer Res,2006,66(17):8319-8126.

58.Turloy EA,Veiseh M,Radisky DC,et al.Mechanisms of Disease:epithelialmesenchymal transition-dose cellular plasticity fuel neoplastic Progression?Nat Clin Pract Oncol,2008,5:280-290.

59.Yang MH,Wu MZ,Chiou SH,et al.Direct regulation of TWIST by HIF-1αPromotesmetastasis.Nature Cell Biology,2008,10:295-305.

60.Li F.Beyond tumorigenesis:cancer stem cells inmetastasis.Cell Research,2007,17:3-14.

61.Wels J,Kaplian RN,Rafii S,et al.Migratory neighbors and distant invaders:tumor associated niche cells.Genes&Dev,2008,22:559-574.

62.Guarino M.Epithelialmesenchymal transition and tumour invasion.Int JBiochem&Cell Biol,2007,39:2153-2160.